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Agitation Alcohol withdrawal symptoms Muscle spasms Sedation Restless legs syndrome Sleepwalking disorder. Benzodiazepines act through the gamma-aminobutyric acid GABA A receptor, which regulates chloride entry into neurons, resulting in neuronal hyperpolarization 1. The dosage of a benzodiazepine will vary depending on the patient and his or her history of sedative use. Although similar in many ways, the choice of an agent is often based on its pharmacokinetic properties, especially onset of action, half-life, and metabolic pathway. Oral dose equivalences of benzodiazepines 2: Agent.

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Also known as benzos, these drugs act as central nervous system CNS sedatives to promote relaxation. Benzos like Xanax are normally prescribed to treat anxiety disorders, alleviating symptoms like excessive worrying and nervousness. Because certain medications are expensive in the U.

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The MHRA reminds healthcare professionals that benzodiazepines and benzodiazepine-like drugs co-prescribed with opioids can produce additive CNS depressant effects, thereby increasing the risk of sedation, respiratory depression, coma, and death. Healthcare professionals are advised to only co-prescribe if there is no alternative and, if necessary, the lowest possible doses should be given for the shortest duration. Patients should be closely monitored for signs of respiratory depression at initiation of treatment and when there is any change in prescribing, such as dose adjustments or new interactions.