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In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate cGMP by inhibiting cGMP specific phosphodiesterase type 5 PDE5 11, 12, 13, 14, 15, 16, 8, 9. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid 11, 12, 13, 14, 15, 16, 8, 9. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late s 7. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Sildenafil is a phosphodiesterase-5 PDE5 inhibitor that is predominantly employed for two primary indications The EMA label also indicates sildenafil for the treatment of pediatric patients aged 1 year to 17 years old with pulmonary arterial hypertension Its effect is more potent on PDE5 than on other known phosphodiesterases 11, 12, 13, 14, 15, 16, 8, 9. In particular, there is a times selectivity over PDE6 which is involved in the phototransduction pathway in the retina 11, 12, 13, 14, 15, 16, 8, 9. There is an times selectivity over PDE1, and over times over PDE 2, 3, 4, 7, 8, 9, 10 and 11 11, 12, 13, 14, 15, 16, 8, 9. Most studies assessed the efficacy of sildenafil approximately 60 minutes post-dose 11, 12, 13, 14, 15, 16, 8, 9.

By increasing blood flow to the penile region, it helps to promote and sustain firm erections, allowing men to regain their confidence and enjoy satisfying sexual experiences. Proven and Trusted: Sildenafil Citrate has a long-standing reputation as a trusted medication for the treatment of erectile dysfunction. This quick response time allows for spontaneity in sexual activity, providing men with the flexibility and freedom to engage in intimate moments when desired. Prolonged Duration: One of the standout advantages of Sildenafil Citrate is its extended duration of action. This extended duration ensures a satisfying and fulfilling experience for both partners. Increased Confidence and Intimacy: Sildenafil Citrate not only improves erectile function but also helps to boost self-confidence and enhance the overall quality of intimate relationships.

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Sildenafil Citrate Powder is an oral therapy for ED. It is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5 PDE5. The specifics of action involve the binding of nitric oxide to the guanylate cyclase receptors, which increases cGMP levels. This produces a smooth muscle relaxation, which in turn opens the pathway for increased blood flow. Viagra provides the ability to produce or maintain an erection.

Sildenafil usually lasts for hours at full potency. It all depends on your health, age, dosage, and sexual activity. It's important to note that Sildenafil and other ED treatments will not give you an erection for the entire period that they are in your system. They simply buy sildenafil citrate powder you to achieve a satisfactory erection when you are sexually stimulated. Your erection will still go down as normal after ejaculation. It details what it does, how it helps to treat ED and various other things you should know.

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