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Introduction: Sildenafil citrate 50 mg is the recommended starting dose for men with erectile dysfunction ED ; however, most men are later titrated to sildenafil mg for improved efficacy. Aim: Assess the tolerability and efficacy of sildenafil initiated at the mg dose in men with ED. Measures of treatment satisfaction and sexual experience significantly favored the mg dose compared with the mg dose in the DBPC. There was no increase in adverse events with the higher dose.

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Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Common side effects include headaches, heartburn, and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5, an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. Pfizer originally discovered the medication in while looking for a treatment for angina. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete sexual intercourse.

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