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The potency of tapentadol is somewhere between that of tramadol and morphine, 7 with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects. Tapentadol is Pregnancy Category C. There are no adequate and well-controlled studies of tapentadol in pregnant women, and tapentadol is not recommended for use in women during and immediately prior to labor and delivery. There are no adequate and well-controlled studies of tapentadol in children. Tapentadol is contraindicated in people with epilepsy or who are otherwise prone to seizures. It raises intracranial pressure so should not be used in people with head injuries, brain tumors, or other conditions which increase intracranial pressure.

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It is not for use on an as-needed basis for pain. Nucynta 50 mg Tapentadol oral solution is indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults. Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, reserve NUCYNTA oral solution for use in patients for whom alternative treatment options e. Ensure accuracy when prescribing, dispensing, and administering NUCYNTA oral solution to avoid dosing errors due to confusion between mg and mL, which could result in accidental overdose and death. Ensure the proper dose is communicated and dispensed.

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