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We described for the first time suspected sADRs associated with ivermectin exposure according to geographical origin. Ivermectin is a drug used worldwide for various indications: onchocerciasis, lymphatic filariasis, strongyloidiasis, human sarcoptic scabies, acarodermatitis and rosacea. Serious post-ivermectin encephalopathies can also occur outside of Loa loa endemic regions but the understanding of the mechanism by which it occurs requires further studies. A new signal concerning two serious toxidermias DRESS syndrome and acute generalized exanthematous pustulosis is also described. Competing interests: The authors have declared that no competing interests exist. Ivermectin is included in the World Health Organization WHO list of essential medicines and is commonly used worldwide.

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