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Mechanism of Action: The active ingredient in Dyloject, diclofenac, is an NSAID that exhibits anti-inflammatory analgesic and antipyretic activities in animal models. Moderate to severe rheumatoid arthritis including acute flares of chronic disease. Moderate to severe ankylosing spondylitis.

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Study selection Randomised controlled trials assessing the efficacy and tolerability of drugs versus placebo or other treatment for sciatica. Pain and disability outcomes were converted to a common 0 to scale. Data were pooled with a random effects model, and the GRADE approach was used in summary conclusions. The evidence to judge the efficacy of non-steroidal anti-inflammatory drugs NSAIDs, corticosteroids, antidepressants, anticonvulsants, muscle relaxants, and opioid analgesics ranged from moderate to low quality.

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Mefenamic acid, and piroxicam and tenoxicam have a spectrum of side effects between that of aspirin and the ibuprofen type. The oxicams have a markedly longer duration of action than the majority of other NSAIDs and are therefore useful in chronic pain. Indometacin is a much more potent anti-inflammatory drug but poorer analgesic than aspirin. It is more likely to produce serious side effects and is only recommended for chronic pain when other analgesics do not work. Paracetamol relieves pain and fever in adults and children, and is the most widely accepted medicine in the United Kingdom for this purpose.

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