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We observed no unique outbreak change pattern during the three largest outbreaks in our data, and These outbreaks were not identified by other methods, since they required 5 years of historical data for the calculation of the thresholds. Percentile and upper confidence interval thresholds were very high and thus failed to detect most outbreaks and they gave the slowest signals in this study. However, those outbreaks signals were the four largest in our data, and Same period Moving threshold Unlike the moving threshold method, this threshold method represents the seasonal pattern from historical data Figure 8. Again, in this category, we observed resembled appearance between the average and median, and the percentile and upper Confidence Interval. Percentile and Upper confidence intervals were able to detect the four largest outbreaks as well.

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Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening, and for emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber.