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Patients with spasticity due to traumatic brain injury should wait at least one year after the injury before consideration of long term intrathecal baclofen therapy. Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multiple organ-system failure and death. Prevention of abrupt discontinuation of intrathecal baclofen requires careful attention to programming and monitoring of the infusion system, refill scheduling and procedures, and pump alarms. Patients and caregivers should be advised of the importance of keeping scheduled refill visits and should be educated on the early symptoms of baclofen withdrawal. Special attention should be given to patients at apparent risk e.

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This medication is a derivative of gamma-aminobutyric acid GABA, prescribed for severe chronic spasticity. It comes as a tablet to take by mouth, with food. The recommended dose is 5 mg three times a day for 3 days 10 mg three times a day for 3 days 15 mg three times a day for 3 days 20 mg three times a day for 3 days. It may be increased if needed. Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly.

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Lioresal Mechanism: How does Lioresal work? GABA released by some nerves causes the electrical activity of other nerves to decrease. Thereafter, additional increases may be necessary but the total daily dose should not exceed a maximum of 80 mg daily 20 mg 4 times daily. Utilize the lowest dose compatible with an optimal response. If benefits are not evident after a reasonable trial period, withdraw patients slowly from the drug. If you miss a Generic Lioresal dose Take it as soon as you remember.

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Relieves muscle spasticity by inhibiting the transmission of reflexes at the spinal cord level. Newly discovered uses off-label. Drowsiness, vertigo, dizziness, psychiatric lioresal without prescription, and muscular weakness. Avoid abrupt discontinuation of the drug. Before you buy baclofen, please remember that this drug not for use in the elderly.

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