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The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider.
Like all medicines, baclofen can cause side effects in some people, but many people have no side effects or only minor ones. These common side effects of baclofen happen in more than 1 in people. There are things you can do to help cope with them If baclofen makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you do not faint, then sit until you feel better. Do not drive, ride a bike or use tools or machinery if you feel dizzy. Do not drink any alcohol as it will make you feel more tired.
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Baclofen in overdose produces a rapid onset of delirium, respiratory depression, coma and seizures. Baclofen is a synthetic derivative of GABA. At a therapeutic dose it acts on spinal GABAb receptors but in overdose this selectivity is lost and the GABA receptors in the brain are targeted resulting in sedation and coma. And like GABAa withdrawal the same situation can occur if a patient suddenly stops baclofen and withdrawal syndromes can manifest. Emergency Physician at Kelowna hospital, British Columbia. Loves the misery of alpine climbing and working in austere environments namely tertiary trauma centres. Toxicokinetics: Rapidly and completely absorbed orally Peak serum concentration in 2 hours Penetrates the blood-brain-barrier Volume of distribution 0. Intoxication will develop within 2 hours, delirium is most evident just prior to the onset of coma. The duration of coma can last 24 — 48 hours.
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It works by helping to relax the muscles. Side Effects Drowsiness, dizziness, weakness, tiredness, headache, trouble sleeping, nausea, increased urination, or constipation may occur. Precautions Before taking baclofen, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Avoid alcoholic beverages. Interactions Drug interactions may change how your medications work or increase your risk for serious side effects. Check the labels on all your medicines such as allergy or cough -and-cold products because they may contain ingredients that cause drowsiness.
What if I am taking other medicines? Are there any side effects? APO-Baclofen contains the active ingredient baclofen. APO-Baclofen is used to reduce the stiffness or spasms in your muscles to help make you more mobile and able to manage your daily activities. These spasms happen in various illnesses such as multiple sclerosis and diseases or injuries of the spinal cord. During treatment, you may be at risk of developing certain side effects.
Baclofen is a muscle relaxer and an antispasmodic agent. Baclofen is used to treat muscle symptoms; such as spasm, pain and stiffness; caused by multiple sclerosis, spinal cord injuries, or other spinal cord disorders. Do not use baclofen at a time when you need muscle tone for safe balance and movement during certain activities. Do not drive or operate heavy machinery until you know how baclofen affects you. Using baclofen may increase your risk of developing an ovarian cyst. Talk with your doctor about your specific risk.
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity such as from a spinal cord injury or multiple sclerosis. Common side effects include sleepiness, weakness, and dizziness. Baclofen was approved for medical use in the United States in Baclofen is primarily used for the treatment of spastic movement disorders, especially in instances of spinal cord injury, cerebral palsy, and multiple sclerosis. Baclofen is sometimes used off-label as a treatment for alcohol use disorder to reduce the risk of relapse and to increase the number of days that a person can go without drinking alcohol abstinence days.
Baclofen is a muscle relaxant and antispasmodic drug that helps alleviate muscle spasms, stiffness, and pain. Doctors may also prescribe baclofen for multiple sclerosis MS, spinal cord injury, and other conditions of the central nervous system. The drug inhibits the transmission of nerve impulses to reduce muscle contractions and pain. In this article, we describe baclofen in more detail, including its uses, how to take it, and the potential side effects and drug interactions. We also answer some frequently asked questions about baclofen. Baclofen has various effects on the body that make it suitable for the treatment of several conditions.
The tablets were prepared by wet granulation. Prior to compression, the baclofen 25mg granules were evaluated for flow and compression characteristics. The excipients used in this study did not alter physicochemical properties of the drug, as tested by the thermal analysis using differential scanning calorimetry. The flow and compression characteristics of the prepared granules significantly improved by virtue of granulation process. Rent this article via DeepDyve.