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Action Produces intolerance to alcohol by blocking oxidation of acetaldehyde by enzyme aldehyde dehydrogenase, resulting in high blood levels of acetaldehyde and unpleasant physical symptoms. Indications Aid in management of alcoholism in selected patients who want to remain in state of enforced sobriety. Contraindications Hypersensitivity to thiuram derivatives used in pesticides and rubber vulcanization; severe myocardial disease or coronary occlusion; psychoses; patients receiving or who have recently received metronidazole, paraldehyde, alcohol or alcohol-containing products. Alcohol: Causes severe alcohol-intolerance reaction. Symptoms include flushing, throbbing in head and neck, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitations, shortness of breath, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision and confusion.
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