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It is a precursor to GABA, glutamate, and glycine in certain brain areas. GHB has been used in the medical setting as a general anesthetic and as treatment for cataplexy, narcolepsy, and alcoholism. GHB is also produced as a result of fermentation, and is found in small quantities in some beers and wines, beef, and small citrus fruits. Succinic semialdehyde dehydrogenase deficiency is a disease that causes GHB to accumulate in the blood. GHB is used for medical purposes in the treatment of narcolepsy 10 and, more rarely, alcohol dependence, 11 12 although there remains uncertainty about its efficacy relative to other pharmacotherapies for alcohol dependence. It is sometimes used off-label for the treatment of fibromyalgia.
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If the bursts contain electrographic seizure activity order disulfiram canada, the coma should be deepened, at times to virtual electrocerebral silence. Phenobarbital may be used as a bridge if initial weaning off pentobarbital results in recurrence of seizures. Silbergleit R, Durkalski V, Lowenstein D, et al: Intramuscular versus intravenous therapy for prehospital status epilepticus. Knake S, Gruener J, Hattemer K, et al: Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. Rossetti A, Reichhart M, Schaller M, et al: Propofol treatment of refractory status epilepticus: a study of 31 episodes.