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Oral semisynthetic aminopenicillin similar to ampicillin; not stable to beta-lactamases of either gram-positive or gram-negative bacteria; more stable to gastric acid than penicillin; more bioavailable than oral ampicillin; commonly used to treat otitis media, bronchitis, sinusitis; also used in combination regimens for H. The American Heart Association AHA recommends amoxicillin extended-release as an alternative to penicillin V for rheumatic fever prophylaxis. The American Heart Association AHA recommends extended-release amoxicillin as an alternative to penicillin V for rheumatic fever prophylaxis.

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