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Nevertheless, iodine contrast agents must be used with caution in patients with thyroid disease and in those with known hypersensitivity to iodine or allergies to food and other drugs. Premedication with corticosteroids is recommended for such patients. Cautious use of contrast agents is indicated in patients with epilepsy, hepato-renal syndrome, severe respiratory disease and diabetes. They should not be administered to patients who are taking metformin for Type agents can increase the risk of lactic acidosis. Adverse reactions to iodine contrast agents are rare, especially with the newer non-ionic dimers of low osmolality.

 

Radioactive iodine is also used to treat thyrotoxicosis. These anti-cancer drugs do not fit into the other groups. Most are cytotoxic in some way and cause the usual side effects. They are used for specific indications.


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Sodium ion channels can be in three different states open, closed or inactivated. Local anaesthetics preferentially bind to channels in the inactive state and prevent them from opening again.


  • HDLs are not atherogenic because of their small size.
  • Side effects of riluzole are nausea, vomiting, tachycardia, headache, dizziness and vertigo.
  • Ion channels, carrier proteins and enzymes can also be targets for drug action.
  • Etanercept can be used either alone or with methotrexate and is given by sub-cutaneous injection twice weekly.
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If this happens, the contrast agent may provoke seizures. LOCAs are the safer contrast agents in this respect.


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This was conducted on Hospital by the chief surgeon Dr Warren in front of an audience of other surgeons. The demonstration was a resounding success and surgeons rapidly adopted the process of anaesthesia.

Authored by Dr. Edwin C Kingsley, MD

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