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The second, retatrutide, has an unprecedented level of efficacy, and could raise the bar for pharmacological obesity treatment. Results from phase II clinical trials of both drugs were announced at a meeting of the American Diabetes Association this month and in the New England Journal of Medicine 1, 2. Orforglipron and retatrutide both mimic hormones produced by the lining of the phentermine 30 mg pink tablets in response to certain nutrients. In the past five years or so, two GLP-1 receptor agonists that lead to substantial weight loss have come on the market, amid much fanfare. One of the drugs, tirzepatide marketed as Mounjaro, has been approved by US regulators only for treating diabetes.

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Gluten sensitivity is a term that is applied interchangeably with intolerance. However, the term should be used to describe patients who can get a variety of symptoms when they eat gluten and feel better on a gluten-free diet but do not have celiac disease. The biopsy is normal and there is no damage to the intestine. Common symptoms of gluten sensitivity include abdominal pain similar to irritable bowel syndrome, fatigue, headaches and paresthesia tingling of the extremities. There is also a possibility that a subgroup of patients with psychiatric disorders like schizophrenia might be affected by gluten sensitivity.