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But other lifestyle changes are still necessary for long-term success. When paired with other lifestyle changes and taken under the supervision of a healthcare professional, these drugs may offer an effective way to lower your weight. Similarly, setmelanotide Imcivree, is intended to treat obesity caused by certain genetic disorders.

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It is prescribed to obese patients whose body mass index is greater than It is used only in the short-term as an aid to dietary changes, exercise, and behavior modification. Mental and mood changes include euphoria, sadness, nervousness, restlessness, sleeplessness, confusion, irritability, unusual thoughts, and hyperactivity.

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The term non-syndromic obesity is sometimes used to exclude these conditions. The thrifty gene hypothesis postulates that, due to dietary scarcity during human evolution, people are prone to obesity. Their ability to take advantage of rare periods of abundance by storing energy as fat would be advantageous during times of varying food availability, and individuals with greater adipose reserves would be more likely to survive famine.

Certain physical and mental illnesses and the pharmaceutical substances used to treat them can increase risk of obesity. Medical illnesses that increase obesity risk include several rare genetic syndromes listed above as well as some congenital or acquired conditions: hypothyroidism, Cushing's syndrome, growth hormone deficiency, and some eating disorders such as binge eating disorder and night eating syndrome.

While genetic influences are important to understanding obesity, they cannot completely explain the dramatic increase seen within specific countries or globally. There are a number of theories as to the cause but most believe it is a combination of various factors. The correlation between social class and BMI varies globally. Research in found that in developed countries women of a high social class were less likely to be obese.

No significant differences were seen among men of different social classes. In the developing world, women, men, and children from high social classes had greater rates of obesity. The decrease in strength of correlation was felt to be due to the effects of globalization. A similar relationship is seen among US states: more adults, even in higher social classes, are obese in more unequal states.

Many explanations have been put forth for associations between BMI and social class. It is thought that in developed countries, the wealthy are able to afford more nutritious food, they are under greater social pressure to remain slim, and have more opportunities along with greater expectations for physical fitness.

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