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There is growing interest in the pharmacological treatment of obesity. Before, there were few weight loss medications approved by the FDA. The advent of Glucagon-like peptide-1 receptor agonists GLP-1 receptor agonists, with brand names like Wegovy and Ozempic, has attracted explosive media attention. It is not always easy to determine which medication is right for a particular individual.

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The dose must be increased gradually over 16 to 20 weeks to arrive at the 2. This progression can help to alleviate side effects, which include gastrointestinal symptoms, headache, dizziness, and fatigue. Semaglutide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia type 2.

Warnings and precautions include acute pancreatitis, gall bladder disease, acute kidney injury especially in patients with severe gastrointestinal reactions, diabetic retinopathy, heart rate increase, suicidal behavior, and ideation. Liraglutide is also a GLP-1 receptor agonist. It is a daily injectable medication that acts on hormones from the gut that send signals to the brain to make the patient feel full quicker and decrease hunger signals.

Side effects of taking liraglutide include nausea, diarrhea, constipation, vomiting, headache, decreased appetite, dyspepsia, fatigue, dizziness, abdominal pain, increased lipase, and renal insufficiency, increased heart rate. It is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 and other precautions and warnings are similar to Semaglutide. Having the combination of two drugs increases efficacy.

Adults with migraines and obesity are good candidates for this weight-loss medication. It is also approved for chronic weight management in pediatric patients aged 12 years and older with a BMI in the 95th percentile or greater standardized for age and gender. Daily doses with four strengths are available, starting at 3. Contraindications include uncontrolled hypertension and coronary artery disease, hyperthyroidism, glaucoma, and sensitivity to stimulants.

Exposure to topiramate during the first trimester of pregnancy increases the risk of oral cleft. An effective contraception in women of reproductive age group is essential. Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain and thereby decrease cravings and appetite.

The most common side effects include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea. This medication should not be prescribed to a patient who has a seizure disorder or who takes opioids for chronic pain. Setmelanotide is a melanocortin-4 receptor agonist indicated for chronic weight management in adult and pediatric patients 6 years of age and older with obesity due to one of several specific rare genetic disorders.

Orlistat is a lipase inhibitor that comes in a capsule and works by blocking the enzyme that breaks down fats consumed through food. In this way, it inhibits the absorption of dietary fats. The undigested fat is then passed through the body. It is intended for use in conjunction with a reduced-calorie diet and is also indicated to reduce the risk of weight regain.

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