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Thus, the number of functioning hepatocytes is reduced, and therefore so is the capacity to metabolize drugs. The process known as first pass metabolism is drastically reduced with ageing. Drugs that would normally undergo this process, achieve far higher blood levels in older patients than would otherwise be expected.

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It is more effective than Buscopan and has a shorter duration of action. A disadvantage is that, because it is a protein, glucagon can provoke hypersensitivity reactions. Metoclopramide is a dopamine antagonist that stimulates cheap accutane emptying and small intestine transit and is used to speed up transit time of barium follow-through examinations. Metoclopramide is also an antiemetic, which can be useful in radiological examinations and to counteract the effects of therapeutic radiography. The antiemetic effect is due to the blocking of dopamine receptors in the chemotrigger zone of the medulla.

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